Papas E
Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, NSW, 2052, Australia.
Exp Eye Res. 1998 Aug;67(2):125-31. doi: 10.1006/exer.1998.0504.
The relationship between induced limbal hyperaemia and lens oxygen transmissibility was investigated in a series of clinical studies in which subjects wore a range of soft contact lenses for eight hours each. Data representing the degree of limbal hyperaemia induced in each case was extracted and subjected to non linear regression analysis with hyperaemia as dependent, and oxygen transmissibility as independent variables. Strong, statistically significant associations were found, particularly when oxygen transmissibility in a 12 mm diameter annular zone at the lens periphery was considered. Best fitting functions were of an inverse form for nasal (r2=0.86, P=0.008) and temporal (r2=0.81, P=0.014) quadrants and a logarithmic form for superior (r2=0.87, P=0.007) and inferior (r2=0. 97, P< 0.005) quadrants. These findings provide support for an hypoxic theory of soft contact lens induced limbal hyperaemia. Estimates based on the logarithmic model suggest a 95% confidence interval for the peripheral oxygen transmissibility required to avoid limbal hyperaemia of 56-274 x 10(-9) (cm s-1) (mlO2 ml-1 x mm Hg).
在一系列临床研究中，对诱导性角膜缘充血与镜片透氧性之间的关系进行了调查。在这些研究中，受试者佩戴一系列软性隐形眼镜，每次佩戴八小时。提取代表每种情况下诱导的角膜缘充血程度的数据，并以充血为因变量、透氧性为自变量进行非线性回归分析。发现了强烈的、具有统计学意义的关联，特别是当考虑镜片周边12毫米直径环形区域的透氧性时。鼻侧象限（r2 = 0.86，P = 0.008）和颞侧象限（r2 = 0.81，P = 0.014）的最佳拟合函数呈反比形式，而上侧象限（r2 = 0.87，P = 0.007）和下侧象限（r2 = 0.97，P < 0.005）的最佳拟合函数呈对数形式。这些发现为软性隐形眼镜诱导角膜缘充血的缺氧理论提供了支持。基于对数模型的估计表明，避免角膜缘充血所需的周边透氧性的95%置信区间为56 - 274 x 10(-9)（厘米·秒-1）（毫升O2·毫升-1·毫米汞柱）。
