在蜱介导的病毒传播中，A2G小鼠基于Mx1的对托高托病毒的抗性被绕过。
Mx1-based resistance to thogoto virus in A2G mice is bypassed in tick-mediated virus delivery.
作者信息
Dessens J T, Nuttall P A
机构信息
Institute of Virology and Environmental Microbiology, Oxford OX1 3SR, United Kingdom.
出版信息
J Virol. 1998 Oct;72(10):8362-4. doi: 10.1128/JVI.72.10.8362-8364.1998.
Abstract
The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.
摘要
干扰素诱导的小鼠Mx1蛋白对包括托高托病毒在内的正粘病毒具有内在抗病毒活性。因此，Mx1(+) A2G小鼠在经针刺或蜱传播病毒攻击后显然具有抗感染能力。然而，蜱传播攻击以及在较小程度上注射与蜱唾液腺提取物混合的病毒导致病毒传播给以A2G小鼠为食的未感染蜱。数据表明，蜱唾液中的免疫调节成分可以克服天然抗病毒机制。
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