Poller L, van den Besselaar A M, Jespersen J, Tripodi A, Houghton D
Central Facility, ECAA, University of Manchester, UK.
Br J Haematol. 1998 Sep;102(4):910-7. doi: 10.1046/j.1365-2141.1998.00866.x.
International sensitivity index calibrations based on the W.H.O. recommended method depend on orthogonal regression analysis. As this is not readily available in statistical packages, comparison has been made with simple linear regression analysis in a study of coagulometer effects on the International Normalized Ratio (INR) at 155 European centres. Sets of seven lyophilized normal and 20 lyophilized artificially depleted abnormal plasmas were provided with five coumarin test plasmas and two European Concerted Action on Anticoagulation reference thromboplastins (low International Sensitivity Index (ISI) human and high ISI rabbit). Local ISI based on the artificially depleted lyophilized plasmas using conventional orthogonal regression gave good correction for local coagulometer effects on the human reagent and minimal correction with the rabbit reagent INR. Results were considerably worse after attempts at correction using calibration based on linear regression analysis with both reagents. The results indicate that calibration of coagulometer prothrombin time systems using simple linear regression is not appropriate.
基于世界卫生组织推荐方法的国际敏感度指数校准依赖于正交回归分析。由于统计软件包中不易获取该方法，在一项针对155个欧洲中心的凝血仪对国际标准化比值（INR）影响的研究中，已将其与简单线性回归分析进行了比较。向七组冻干正常血浆和20组冻干人工稀释异常血浆中加入了五种香豆素测试血浆以及两种欧洲抗凝协作组参考凝血活酶（低国际敏感度指数（ISI）的人源性和高ISI的兔源性）。使用传统正交回归法基于人工稀释的冻干血浆得出的局部ISI，能很好地校正凝血仪对人源性试剂的局部影响，而对兔源性试剂的INR校正作用极小。在用两种试剂基于线性回归分析进行校准校正后，结果要差得多。结果表明，使用简单线性回归对凝血仪凝血酶原时间系统进行校准是不合适的。
