Syntheses of some 4-[(4-chloro-5-methyl-2-methylthiophenyl)sulphonyl]-1-(aryl)semicarbazi des and N-[(4-chloro-5-methyl-2-methylthiophenyl)sulphonyl]-N'-(4-chlorophenyl) urea with potential anticancer activity.

A series of 4-[(4-chloro-5-methyl-2-methylthiophenyl) sulphonyl]-1-(aryl)semicarbazides [IV-XI] and N-[(4-chloro-5-methylthiophenyl)sulphonyl]-N'-(4-chlorophenyl)urea [XII] were prepared and evaluated in vitro for anticancer activity [IV-VII, IX-XII]. All compounds exhibited weak [V-VII, IX] or moderate [IV, X-XII] activity against some human tumor cell lines, whereas the compound [XII] showed a relatively high activity (Table 3).