Brzozowski Z
Department of Chemical Drug Technology, Medical University, Gdańsk, Poland.
Acta Pol Pharm. 1998 May-Jun;55(3):233-8.
A series of 4-[(4-chloro-5-methyl-2-methylthiophenyl) sulphonyl]-1-(aryl)semicarbazides [IV-XI] and N-[(4-chloro-5-methylthiophenyl)sulphonyl]-N'-(4-chlorophenyl)urea [XII] were prepared and evaluated in vitro for anticancer activity [IV-VII, IX-XII]. All compounds exhibited weak [V-VII, IX] or moderate [IV, X-XII] activity against some human tumor cell lines, whereas the compound [XII] showed a relatively high activity (Table 3).
制备了一系列4-[(4-氯-5-甲基-2-甲基硫代苯基)磺酰基]-1-(芳基)氨基脲[IV-XI]和N-[(4-氯-5-甲基硫代苯基)磺酰基]-N'-(4-氯苯基)脲[XII]，并对其进行了体外抗癌活性评估[IV-VII，IX-XII]。所有化合物对某些人类肿瘤细胞系均表现出弱活性[V-VII，IX]或中等活性[IV，X-XII]，而化合物[XII]表现出相对较高的活性(表3)。
