人体肢体毛细血管滤过系数：测量部位的重要性。

Limb capillary filtration coefficient in human subjects: the importance of the site of measurement.

作者信息

Mahy I R, Lewis D M, Tooke J E

机构信息

Department of Vascular Medicine, University of Exeter, UK.

出版信息

Physiol Meas. 1998 Aug;19(3):339-43. doi: 10.1088/0967-3334/19/3/002.

DOI:10.1088/0967-3334/19/3/002

PMID:9735884

Abstract

Capillary filtration coefficient is a critical determinant of fluid flux across the microvascular wall. Changes in capillary filtration coefficient have been described in a number of disease processes. Measurement is typically made by venous occlusion plethysmography using either the upper or lower limb, but a variety of measurement protocols have been used and the importance of the site of measurement remains unclear. In this study, forearm and calf capillary filtration coefficient were measured in healthy volunteers, either simultaneously (group A; n = 11) or sequentially in random order (group B; n = 11) using venous occlusion plethysmography, with the subject supine and the limb at heart level. In both studies capillary filtration coefficient was significantly higher when measured at the forearm than at the calf (group A: 6.1 +/- 1.0 versus 3.7 +/- 1.1 x 10(-3) ml min(-1) mmHg(-1) 100 ml(-1) (mean +/- SD), p < 0.01; group B: 5.1 +/- 1.2 versus 3.2 +/- 1.1 x 10(-3) ml min(-1) mmHg(-1) 100 ml(-1), p < 0.01). Isovolumetric venous pressure (the maximum pressure at which there is neither net filtration nor absorption at the microvascular wall) was similar in upper and lower limbs in both groups of subjects. We conclude that limb capillary filtration coefficient is dependent on the site of measurement. Caution is required when comparing data recorded at different sites even if corrected for the volume of soft tissue under study.

摘要

毛细血管滤过系数是决定液体通过微血管壁流量的关键因素。在许多疾病过程中都已描述了毛细血管滤过系数的变化。测量通常采用静脉阻断体积描记法，测量部位可为上肢或下肢，但使用了多种测量方案，测量部位的重要性仍不明确。在本研究中，对健康志愿者采用静脉阻断体积描记法，分别同时测量前臂和小腿的毛细血管滤过系数（A组，n = 11）或随机顺序测量（B组，n = 11），受试者仰卧，肢体处于心脏水平。在两项研究中，在前臂测量时毛细血管滤过系数均显著高于小腿（A组：6.1±1.0对比3.7±1.1×10⁻³ ml·min⁻¹·mmHg⁻¹·100 ml⁻¹（均值±标准差），p < 0.01；B组：5.1±1.2对比3.2±1.1×10⁻³ ml·min⁻¹·mmHg⁻¹·100 ml⁻¹，p < 0.01）。两组受试者的等容静脉压（微血管壁既无净滤过也无吸收时的最大压力）在上肢和下肢相似。我们得出结论，肢体毛细血管滤过系数取决于测量部位。即使对所研究软组织的体积进行了校正，在比较不同部位记录的数据时仍需谨慎。