Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives.
作者信息
Holland K P, Elford H L, Bracchi V, Annis C G, Schuster S M, Chakrabarti D
机构信息
Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2456-8. doi: 10.1128/AAC.42.9.2456.
Abstract
Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.
摘要
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