遗传密码的起源：转运RNA比其合成酶更古老？
Genetic code origins: tRNAs older than their synthetases?
作者信息
Ribas de Pouplana L, Turner R J, Steer B A, Schimmel P
机构信息
The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11295-300. doi: 10.1073/pnas.95.19.11295.
Abstract
We present a phylogenetic analysis to determine whether a given tRNA molecule was established in evolution before its cognate aminoacyl-tRNA synthetase. The earlier appearance of tRNA versus their metabolically related enzymes is a prediction of the RNA world theory, but the available synthetase and tRNA sequences previously had not allowed a formal comparison of their relative time of appearance. Using data recently obtained from the emerging genome projects, our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the establishment of the identity of lysine tRNA.
摘要
我们进行了一项系统发育分析，以确定特定的转运RNA（tRNA）分子在其同源氨酰tRNA合成酶之前是否已在进化过程中确立。tRNA相对于其代谢相关酶更早出现是RNA世界理论的一个预测，但先前可用的合成酶和tRNA序列并不允许对它们相对出现时间进行正式比较。利用最近从新兴基因组计划中获得的数据，我们的分析表明，赖氨酸tRNA的身份确立在进化上先于赖氨酸tRNA合成酶的现存形式。
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