静脉注射组胺对正常男性静态肺顺应性和气道阻力的影响。

Effects of intravenous histamine on static lung compliance and airway resistance in normal man.

作者信息

Laitinen L A, Empey D W, Poppius H, Lemen R J, Gold W M, Nadel J A

出版信息

Am Rev Respir Dis. 1976 Aug;114(2):291-5. doi: 10.1164/arrd.1976.114.2.291.

DOI:10.1164/arrd.1976.114.2.291

Abstract

Static lung compliance and airway resistance were measured in 30 experiments on 6 healthy subjects after intravenous injection of a bolus of histamine (4 mug per kg of body weight). Analysis of the pooled results showed a significant decrease in static lung compliance (maximal mean decrease,--16 per cent occurring 20 sec after injection). There was no significant change in functional residual capacity or vital capacity after injection of the histamine. Administration of propranolol (a beta-adrenergic blocking agent) did not significantly enhance the responses to histamine. The results suggested that humans, like other species, can constrict peripheral airways sufficiently to produce alterations in the static elastic properties of the lungs.

摘要

在6名健康受试者身上进行了30次实验，静脉注射一剂组胺（每公斤体重4微克）后，测量了静态肺顺应性和气道阻力。对汇总结果的分析显示，静态肺顺应性显著降低（最大平均降低-16%，在注射后20秒出现）。注射组胺后，功能残气量或肺活量没有显著变化。给予普萘洛尔（一种β-肾上腺素能阻滞剂）并没有显著增强对组胺的反应。结果表明，人类与其他物种一样，可以充分收缩外周气道，从而改变肺的静态弹性特性。