Hanby A M, McKee P, Jeffery M, Grayson W, Dublin E, Poulsom R, Maguire B
Hedley Atkins/ICRF Breast Pathology Laboratory, Guy's Hospital, London, England, United Kingdom.
Am J Surg Pathol. 1998 Sep;22(9):1125-31. doi: 10.1097/00000478-199809000-00012.
Mucinous carcinoma may present at various sites, including the breast and the gastrointestinal tract. Rarely, such tumors arise within the skin. Comparatively, breast lesions are relatively common and usually associated with a good prognosis. When pure, they are typically estrogen (ER) and progesterone receptor (PR) positive and responsive to tamoxifen. The authors studied 12 mucinous carcinomas of the skin and compared the morphology with that of typical mammary lesions. The authors also evaluated for expression of estrogen receptor, progesterone receptor, and the mucus-associated peptides of the trefoil factor family (TFF), TFF1 (formerly pS2) and TFF2 (formerly SP), using immunohistochemistry. The localization of mRNAs for TFF1, TFF2, and TFF3 (formally ITF) was also studied in a subset of three tumors, using in-situ hybridization with S35 labeled riboprobes. The Grimelius stain was used to look for evidence of neuroendocrine differentiation. Eight resembled type A mucinous carcinomas of the breast, two resembled type B, and one had composite features. The 12th was a papillary neoplasm. The two type B tumors exhibited argyrophilia. All showed strong nuclear staining with the estrogen receptor antibody but a more varied pattern with antibodies to progesterone receptor and TFF1. None labeled for TFF2. The detection of TFF1 in mammalian skin is a novel finding. Cutaneous mucinous carcinoma shows strong similarities to its mammary counterpart, including expression of estrogen receptor, TFF1, and TFF3 mRNA. These observations suggest that some mucinous carcinomas of the skin might respond to antiestrogenic therapies.
黏液腺癌可出现在包括乳腺和胃肠道在内的不同部位。此类肿瘤很少发生于皮肤。相比之下，乳腺病变更为常见，且通常预后良好。单纯性黏液腺癌通常雌激素受体（ER）和孕激素受体（PR）呈阳性，对他莫昔芬有反应。作者研究了12例皮肤黏液腺癌，并将其形态与典型乳腺病变进行比较。作者还采用免疫组化法评估雌激素受体、孕激素受体以及三叶因子家族（TFF）的黏液相关肽TFF1（原名pS2）和TFF2（原名SP）的表达情况。还使用与S35标记的核糖探针进行原位杂交，在三个肿瘤的子集中研究了TFF1、TFF2和TFF3（原名ITF）的mRNA定位。采用Grimelius染色寻找神经内分泌分化的证据。8例类似乳腺A型黏液腺癌，2例类似B型，1例具有复合特征。第12例为乳头状肿瘤。2例B型肿瘤显示嗜银性。所有肿瘤雌激素受体抗体染色均呈强核染色，但孕激素受体和TFF1抗体染色模式更多样化。均未检测到TFF2。在哺乳动物皮肤中检测到TFF1是一项新发现。皮肤黏液腺癌与其乳腺对应物表现出很强的相似性，包括雌激素受体、TFF1和TFF3 mRNA的表达。这些观察结果表明，一些皮肤黏液腺癌可能对抗雌激素治疗有反应。
