麻风病损中诱导型一氧化氮合酶和转化生长因子-β（TGF-β）的免疫细胞化学定位
Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-beta) in leprosy lesions.
作者信息
Khanolkar-Young S, Snowdon D, Lockwood D N
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK.
出版信息
Clin Exp Immunol. 1998 Sep;113(3):438-42. doi: 10.1046/j.1365-2249.1998.00669.x.
Abstract
Inducible nitric oxide synthase (iNOS) and TGF-beta were localized by immunocytochemistry in skin lesions from patients across the leprosy spectrum, and from patients undergoing reversal reaction. iNOS expression was highest at the tuberculoid pole of the spectrum, and increased during reversal reaction. TGF-beta was observed throughout the leprosy spectrum, but was highest at the lepromatous pole. Levels of TGF-beta decreased during reversal reaction. Reduced levels of TGF-beta may contribute to unregulated inflammatory responses during reactional episodes.
摘要
通过免疫细胞化学方法，在麻风病谱系各型患者以及发生逆转反应的患者的皮肤损害中，对诱导型一氧化氮合酶（iNOS）和转化生长因子-β（TGF-β）进行了定位。iNOS表达在谱系的结核样型一端最高，且在逆转反应期间增加。TGF-β在整个麻风病谱系中均有观察到，但在瘤型一端最高。TGF-β水平在逆转反应期间降低。TGF-β水平降低可能导致反应期炎症反应失控。
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