肺癌患者外周肺组织DNA中的8-羟基脱氧鸟苷水平升高。
Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA.
作者信息
Inoue M, Osaki T, Noguchi M, Hirohashi S, Yasumoto K, Kasai H
机构信息
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, School of Medicine, University of Occupational and Environmental Health, Kitakyushu.
出版信息
Jpn J Cancer Res. 1998 Jul;89(7):691-5. doi: 10.1111/j.1349-7006.1998.tb03272.x.
Abstract
The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).
摘要
比较了肺癌患者（n = 70）和非癌症患者对照组（n = 15）人肺组织外周部分的8-羟基脱氧鸟苷（8-OH-dG）水平。与非癌症对照组相比，在肺癌组、腺癌组和非腺癌组（主要为鳞状细胞癌）中均观察到8-OH-dG水平升高。该结果表明活性氧部分参与了肺癌（腺癌和非腺癌）的诱导。
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