接受急性和慢性治疗的哮喘患者口服麻黄碱后的药代动力学。
The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.
作者信息
Pickup M E, May C S, Ssendagire R, Paterson J W
出版信息
Br J Clin Pharmacol. 1976 Feb;3(1):123-34. doi: 10.1111/j.1365-2125.1976.tb00579.x.
Abstract
1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate. 2 Pharmacokinetic assessment of the data indicated no significant intra-subject changes in kinetic parameters before or after chronic treatment with ephedrine HCl (11 mg three times a day) alone or in combination. 3 Tolerance to these therapeutic doses, if it occurs, is therefore not disposition-related but rather to pharmacodynamic changes.
摘要
已对10名哮喘患者的麻黄碱血浆水平进行了测量，这些患者单独服用单剂量盐酸麻黄碱（22毫克），以及与茶碱和一种巴比妥酸盐联合服用。
对数据的药代动力学评估表明，单独或联合使用盐酸麻黄碱（每天3次，每次11毫克）进行慢性治疗前后，受试者体内的动力学参数没有显著变化。
因此，如果出现对这些治疗剂量的耐受性，并非与药物处置相关，而是与药效学变化有关。
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本文引用的文献
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Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output.麻黄碱在人体中的吸收、代谢及排泄。I. 尿液pH值及尿量的影响。
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