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老年人的谵妄。最佳管理。

Delirium in the elderly. Optimal management.

作者信息

Flacker J M, Marcantonio E R

机构信息

Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Drugs Aging. 1998 Aug;13(2):119-30. doi: 10.2165/00002512-199813020-00004.

DOI:10.2165/00002512-199813020-00004
PMID:9739501
Abstract

Delirium is common, morbid and costly, especially among hospitalised elderly patients. Nonetheless, it remains under-recognised and often poorly managed. This article summarises the 5 key steps in the optimal management of delirium. The first step is to precisely define the syndrome of delirium, using key features described in the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) [DSM-IV] or the Confusion Assessment Method. Key features include an acute onset of mental status change, fluctuating course, the presence of inattention, and either disorganised thinking or an altered level of of consciousness. The second step involves the identification of patients at high risk of delirium before it develops, so that preventive measures can be implemented. Risk factors for delirium include advanced age, dementia, impaired functional status, chronic comorbidities and medications, and the severity of the acute illness or surgery. The third step is improved recognition of delirium. Very often, the presence of delirium is neither diagnosed nor properly documented in the medical record. The fourth step is to appropriately evaluate the delirious patient to assess all important contributors to the syndrome. This evaluation will usually involve a careful history, medication review, physical examination and selected laboratory testing. The fifth, and most important, step is the management of the delirious patient. The key elements of management are treating the primary condition(s) leading to delirium, removing all treatable contributing factors, maintaining behavioural control, and supporting the patient and their family.

摘要

谵妄很常见,病情严重且代价高昂,在住院老年患者中尤为如此。尽管如此,它仍然未得到充分认识,管理往往也不到位。本文总结了谵妄优化管理的5个关键步骤。第一步是使用《精神疾病诊断与统计手册》(第四版)[DSM-IV]或《意识错乱评估方法》中描述的关键特征来精确界定谵妄综合征。关键特征包括精神状态改变急性起病、病程波动、注意力不集中,以及思维紊乱或意识水平改变。第二步是在谵妄发生前识别高风险患者,以便实施预防措施。谵妄的风险因素包括高龄、痴呆、功能状态受损、慢性合并症和药物,以及急性疾病或手术的严重程度。第三步是提高对谵妄的识别。谵妄的存在常常在病历中既未被诊断也未得到妥善记录。第四步是对谵妄患者进行适当评估,以评估导致该综合征的所有重要因素。这种评估通常包括仔细询问病史、审查用药情况、体格检查和选择实验室检查。第五步也是最重要的一步是对谵妄患者进行管理。管理的关键要素是治疗导致谵妄的原发疾病,消除所有可治疗的促成因素,维持行为控制,并为患者及其家属提供支持。

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2
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引用本文的文献

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Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital.氟哌啶醇过量治疗伴有谵妄的躁动老年住院患者:来自社区教学医院的回顾性图表回顾。
Drugs Aging. 2013 Aug;30(8):639-44. doi: 10.1007/s40266-013-0087-7.
2
Delirium in hospitalized elderly patients and post-discharge mortality.住院老年患者谵妄与出院后死亡率。
Clinics (Sao Paulo). 2010 Mar;65(3):251-5. doi: 10.1590/S1807-59322010000300003.
3
Predicting early mortality among elderly patients hospitalised in medical wards via emergency department: the SAFES cohort study.

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