吲哚洛尔对高血压患者血浆肾素活性及血压的影响。
The effect of pindolol on plasma renin activity and blood pressure in hypertensive patients.
作者信息
Lancaster R, Goodwin T J, Peart W S
出版信息
Br J Clin Pharmacol. 1976 Jun;3(3):453-60. doi: 10.1111/j.1365-2125.1976.tb00621.x.
Abstract
1 The effect of pindolol administered to twenty-six patients with hypertension of unknown origin was compared with respect to blood pressure and plasma renin activity change after increase of the dose over a period of 6 weeks. 2 There was no clear correlation between the fall of plasma renin activity, which in some patients was very marked, and the fall in blood pressure. Some patients with a fall in plasma renin activity did not drop their pressure. Conversely, some with a fall of pressure did not drop their plasma renin activity. 3 The addition of hydrochlorothiazide to the pindolol finally caused further lowering of the blood pressure in all but one patient and the plasma renin activity rose in all but two patinets. There was no clear correlation between change in plasma renin activity and the effect on blood pressure.
摘要
- 对26例原发性高血压患者给予吲哚洛尔，在6周内增加剂量，比较其对血压和血浆肾素活性变化的影响。2. 血浆肾素活性的下降（在一些患者中非常明显）与血压下降之间没有明显的相关性。一些血浆肾素活性下降的患者血压并未降低。相反，一些血压下降的患者血浆肾素活性并未降低。3. 在吲哚洛尔基础上加用氢氯噻嗪后，除1例患者外，其他所有患者血压进一步降低，除2例患者外，其他所有患者血浆肾素活性升高。血浆肾素活性的变化与对血压的影响之间没有明显的相关性。
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