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发育性语言障碍儿童大脑外侧裂内正常的解剖学不对称性。

Normal intrasylvian anatomical asymmetry in children with developmental language disorder.

作者信息

Preis S, Jäncke L, Schittler P, Huang Y, Steinmetz H

机构信息

Department of Pediatrics, Heinrich-Heine-Universität, Düsseldorf, Germany.

出版信息

Neuropsychologia. 1998 Sep;36(9):849-55. doi: 10.1016/s0028-3932(98)00033-5.

DOI:10.1016/s0028-3932(98)00033-5
PMID:9740358
Abstract

Symmetry of posterior intrasylvian cortices (e.g., planum temporale, planum parietale) has been suggested to represent a risk factor for developmental disorders of language and reading. Using high-resolution magnetic resonance morphometry, we studied 21 right-handed children with developmental language disorder of the phonologic-syntactic type, and found normal left-right asymmetry of the planum temporale and planum parietale when compared with 21 matched controls. The planum temporale was bilaterally smaller in the affected children, a finding accounted for by their approximately 7% smaller forebrain size. Our data do not support a role of gross visible unilateral or bilateral abnormalities of posterior intrasylvian ontogenesis in this disorder.

摘要

大脑外侧裂后皮质(如颞平面、顶平面)的对称性已被认为是语言和阅读发育障碍的一个风险因素。我们使用高分辨率磁共振形态测量法对21名患有音韵-句法型发育性语言障碍的右利手儿童进行了研究,发现与21名匹配的对照组相比,颞平面和顶平面的左右不对称性正常。患病儿童的颞平面双侧较小,这一发现可归因于他们的前脑大小约小7%。我们的数据不支持大脑外侧裂后发育过程中明显可见的单侧或双侧异常在该疾病中起作用。

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