Pollack S, Aisen P, Lasky F D, Vanderhoff G
Br J Haematol. 1976 Oct;34(2):231-5. doi: 10.1111/j.1365-2141.1976.tb00193.x.
Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin-bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. A possible mechanism for this facilitated exchange is offered.
去铁胺广泛用于治疗库利贫血中的铁过载，它与铁结合紧密，理论上应能定量地从转铁蛋白中去除铁。然而，体内和体外研究均未能证明化学计量过量的去铁胺能显著消耗与转铁蛋白结合的铁。不过，能够与转铁蛋白和三价铁形成三元复合物的低分子量螯合剂，可以促进铁从转铁蛋白快速转移至去铁胺。文中提出了这种促进交换的可能机制。
