Wu H H, Silvernagel S W
Department of Pathology, Ball Memorial Hospital, Muncie, Indiana 47303, USA.
Diagn Cytopathol. 1998 Sep;19(3):186-9. doi: 10.1002/(sici)1097-0339(199809)19:3<186::aid-dc6>3.0.co;2-b.
An oncocytic carcinoma of the submandibular gland diagnosed by fine-needle aspiration is reported. Cytologically, the tumor cells occurred singly, in three-dimensional clusters and in multilayered sheets. The cells had round-to-oval, centrally or eccentrically located nuclei with fine chromatin and prominent nucleoli. Many cells contained abundant granular cytoplasm and well-defined cell borders; however, several stripped nuclei with prominent nucleoli were also noted in the background. Follow-up histologic examination showed tumor cells arising from right submandibular gland and metastasizing to six of 14 cervical lymph nodes. Ultrastructural study demonstrated tumor cells packed with mitochondria in the cytoplasm. The patient was alive with no evidence of disease 6 months after the surgery.
报告了1例通过细针穿刺诊断的下颌下腺嗜酸性细胞癌。细胞学上，肿瘤细胞呈单个、三维细胞团和多层片状排列。细胞呈圆形至椭圆形，细胞核位于中央或偏心，染色质细腻，核仁明显。许多细胞含有丰富的颗粒状细胞质和清晰的细胞边界；然而，背景中也可见到几个核仁明显的裸核。后续组织学检查显示肿瘤细胞起源于右下颌下腺，并转移至14个颈部淋巴结中的6个。超微结构研究显示肿瘤细胞的细胞质中充满线粒体。患者术后6个月仍存活，无疾病证据。
