Krings T, Naujokat C, von Keyserlingk D G
Institute of Neuroanatomy, RWTH Clinic Aachen, Germany.
Electroencephalogr Clin Neurophysiol. 1998 Apr;109(2):85-93. doi: 10.1016/s0924-980x(97)00078-7.
Cortical motor representation of 12 muscles of the trunk and the upper and lower extremity was investigated in 18 healthy subjects using focal transcranial magnetic stimulation (TMS) in conjunction with a frameless stereotactic system (FSS). This combination allowed us to orientate stimulation sites to the individual central sulcus rather than to bony landmarks. Distinct but overlapping areas of muscle representation were identified and the 3-dimensional representation of those 12 muscles along the course of the central sulcus was obtained. With increasing stimulus intensity, the cortical output maps changed in that more muscles became excitable, motor evoked potential (MEP) amplitude and size of the responsive area increased and latency of the MEP decreased. These effects were more pronounced for proximal than for distal muscles, indicating a more widespread organization of corticospinal motor projection related to proximal muscles. The combination of TMS and FSS represents a method with which functional information can be directly related to underlying cortical anatomy. This correlation will be useful in the assessment of higher brain functions with TMS.
利用聚焦经颅磁刺激（TMS）结合无框架立体定向系统（FSS），对18名健康受试者躯干及上下肢的12块肌肉的皮质运动代表区进行了研究。这种结合使我们能够将刺激部位定位到个体的中央沟，而不是骨性标志。确定了不同但重叠的肌肉代表区，并获得了这12块肌肉沿中央沟走行的三维代表区。随着刺激强度的增加，皮质输出图谱发生变化，更多肌肉变得可兴奋，运动诱发电位（MEP）幅度和反应区大小增加，MEP潜伏期缩短。这些效应在近端肌肉中比在远端肌肉中更明显，表明与近端肌肉相关的皮质脊髓运动投射组织更广泛。TMS和FSS的结合代表了一种可将功能信息直接与潜在皮质解剖结构相关联的方法。这种关联将有助于利用TMS评估高级脑功能。
