锂盐给药对患者的不可逆影响。
An irreversible effect of lithium administration to patients.
作者信息
Lingsch C, Martin K
出版信息
Br J Pharmacol. 1976 Jul;57(3):323-7. doi: 10.1111/j.1476-5381.1976.tb07669.x.
Abstract
1 Lithium administration to patients leads to a pronounced inhibition (about 90%) of the choline transport system in erythrocytes. The transport system does not recover when ghosts are prepared from the erythrocytes, thereby removing intracellular as well as extracellular lithium. 2 When a patient is taken off lithium, the choline transport in erythrocytes recovers only very slowly over a period of three months, i.e. at about the same rate at which the erythrocytes that had been exposed to lithium are replaced by new cells. 3 It is concluded that therapeutic concentrations of lithium produce an irreversible inhibition of the choline transport system in human erythrocytes.
摘要
- 给患者服用锂会导致红细胞中胆碱转运系统受到显著抑制（约90%）。当从红细胞制备血影时，该转运系统无法恢复，从而去除细胞内和细胞外的锂。2. 当患者停止服用锂时，红细胞中的胆碱转运在三个月的时间内恢复得非常缓慢，即与暴露于锂的红细胞被新细胞替代的速度大致相同。3. 得出的结论是，治疗浓度的锂会对人类红细胞中的胆碱转运系统产生不可逆的抑制作用。
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引用本文的文献
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Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate.长期接受锂盐或丙戊酸钠治疗的双相情感障碍心境正常患者，其脑内胆碱浓度可能不会改变。
Ann Gen Hosp Psychiatry. 2004 Jul 30;3(1):13. doi: 10.1186/1475-2832-3-13.
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Lithium, membranes, and manic-depressive illness.锂、细胞膜与躁郁症
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Erythrocyte choline concentrations are elevated in manic patients.躁狂症患者的红细胞胆碱浓度升高。
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The effect of lithium on choline transport in human erythrocytes.锂对人红细胞中胆碱转运的影响。
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本文引用的文献
1
Uptake of some quaternary ammonium ions by human erythrocytes.人红细胞对某些季铵离子的摄取。
J Gen Physiol. 1966 Jul;49(6):1147-60. doi: 10.1085/jgp.0491147.
2
Some properties of an SH group essential for choline transport in human erythrocytes.人红细胞中胆碱转运所需的巯基（SH）基团的一些特性。
J Physiol. 1971 Mar;213(3):647-64. doi: 10.1113/jphysiol.1971.sp009406.
3
Effects of lithium and of pH on synaptosomal metabolism of noradrenaline.
Nature. 1970 Dec 26;228(5278):1301-3. doi: 10.1038/2281301a0.
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Extracellular cations and the movement of choline across the erythrocyte membrane.细胞外阳离子与胆碱跨红细胞膜的移动
J Physiol. 1972 Jul;224(1):207-30. doi: 10.1113/jphysiol.1972.sp009890.
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Adenyl cyclase activity in kidneys of rats with lithium-induced polyuria.
Acta Pharmacol Toxicol (Copenh). 1972;31(3):203-8. doi: 10.1111/j.1600-0773.1972.tb00714.x.
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