微电泳施加的L-3,4-二羟基苯丙氨酸（多巴）对单个皮层神经元的作用。
The action of microelectrophoretically applied L-3,4-dihydroxyphenylalanine (DOPA) on single cortical neurones.
作者信息
Bevan P, Bradshaw C M, Szabadi E
出版信息
Br J Pharmacol. 1976 Oct;58(2):239-45. doi: 10.1111/j.1476-5381.1976.tb10401.x.
The technique of microelectrophoresis was used in order to compare the actions of L-3,4-dihydroxyphenylalanine (DOPA) and noradrenaline on single neurones in the cerebral cortices of cats and rats. DOPA could both excite and depress cortical neurones. Cells excited by DOPA were also excited by noradrenaline and cells depressed by DOPA were also depressed by noradrenaline. In the case of both excitatory and depressant responses, DOPA appeared to be less potent than noradrenaline. Responses to DOPA and noradrenaline could be antagonized by phentolamine and propranolol. Responses to acetylcholine were not affected. Responses to acetylcholine, but not responses to DOPA, were antagonized by atropine. The results indicate that locally applied DOPA may mimic the actions of noradrenaline on cortical neurones. Possible mechanisms for these effects of DOPA are discussed.
采用微电泳技术比较L-3,4-二羟基苯丙氨酸（多巴）和去甲肾上腺素对猫和大鼠大脑皮质单个神经元的作用。多巴既能兴奋也能抑制皮质神经元。被多巴兴奋的细胞也会被去甲肾上腺素兴奋，被多巴抑制的细胞也会被去甲肾上腺素抑制。在兴奋和抑制反应的情况下，多巴的效力似乎比去甲肾上腺素弱。对多巴和去甲肾上腺素的反应可被酚妥拉明和普萘洛尔拮抗。对乙酰胆碱的反应不受影响。对乙酰胆碱的反应（而非对多巴的反应）可被阿托品拮抗。结果表明，局部应用的多巴可能模拟去甲肾上腺素对皮质神经元的作用。文中讨论了多巴产生这些效应的可能机制。
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