Castle P E, Hoen T E, Whaley K J, Cone R A
Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.
Contraception. 1998 Jul;58(1):51-60. doi: 10.1016/s0010-7824(98)00059-6.
Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products.
新型阴道产品（如微生物杀灭剂和避孕药）的研发需要对其生育影响进行体内测试。与在子宫内授精的大鼠和小鼠等较小的实验动物不同，兔子通过阴道授精，因此作为测试阴道避孕药物的动物模型很有价值。与非人灵长类动物相比，兔子价格低廉且易于处理，并且经常被用于测试阴道药物对生育的影响。我们回顾了相关文献，并报告了一些研究结果，这些结果为在测试新型阴道产品时有效使用和改进兔子避孕模型提供了指导。
