Bruno M J, van Dorp W T, Ferwerda J, Dekker W, Schut N H
Department of Internal Medicine, Haarlem, The Netherlands.
Eur J Gastroenterol Hepatol. 1998 Aug;10(8):717-20.
Beta2-microglobulin (A beta2M) amyloidosis is a relatively new secondary amyloidosis associated with renal failure and haemo- and peritoneal dialysis. Although beta2-microglobulin depositions are systemic, clinical manifestations are limited to articular and para-articular disease in most cases. A very limited number of patients have been reported with extra-articular manifestations including those of the gastrointestinal tract. We report on a patient who was treated with haemodialysis for 23 years and developed colonic pseudo-obstruction due to A beta2M amyloidosis.
β2微球蛋白（Aβ2M）淀粉样变性是一种相对较新的继发性淀粉样变性，与肾衰竭以及血液透析和腹膜透析相关。尽管β2微球蛋白沉积是全身性的，但在大多数情况下，临床表现仅限于关节和关节周围疾病。据报道，仅有极少数患者出现包括胃肠道表现在内的关节外表现。我们报告了一名接受血液透析23年的患者，该患者因Aβ2M淀粉样变性而发生结肠假性梗阻。
