Fleischman D A, Gabrieli J D, Reminger S L, Vaidya C J, Bennett D A
Department of Neurological Sciences, Rush Medical College; Rush Alzheimer's Disease Center, Chicago, IL 60612, USA.
J Int Neuropsychol Soc. 1998 Sep;4(5):435-46. doi: 10.1017/s1355617798455036.
Priming for line drawings of real and nonreal objects was examined in an object decision task for 16 patients with Alzheimer's disease (AD) and 16 normal elderly control (NC) participants. In two study phases, participants decided if objects were real or nonreal. In an implicit test phase, real/nonreal decisions were made for studied and unstudied objects, and priming was measured as the difference in decision speed or accuracy between studied and unstudied objects. In an explicit test phase, yes/no recognition was measured for real and nonreal objects. AD patients had impaired explicit memory for real and nonreal objects and intact repetition priming for real objects. By the latency measure, both AD and NC groups showed priming for nonreal objects but in opposite ways. Classification decisions about studied relative to nonstudied nonreal objects were slower for the AD patients, whereas such decisions were faster for the NC participants. Classification decisions of both groups were less accurate for repeated nonreal objects. These results support the claim that AD patients with mild cognitive impairment show normal perceptual priming. The AD inhibition for studied nonreal objects is discussed in terms of the decision conflict that occurs when recollection of source is not available to counter the influence of familiarity.
在一项物体判断任务中，对16名阿尔茨海默病（AD）患者和16名正常老年对照（NC）参与者进行了真实和非真实物体线条图启动效应的研究。在两个研究阶段，参与者判断物体是真实的还是非真实的。在一个内隐测试阶段，对已研究和未研究的物体进行真实/非真实判断，并将启动效应测量为已研究和未研究物体之间决策速度或准确性的差异。在一个外显测试阶段，对真实和非真实物体进行是/否识别测量。AD患者对真实和非真实物体的外显记忆受损，但对真实物体有完整的重复启动效应。通过潜伏期测量，AD组和NC组都表现出对非真实物体的启动效应，但方式相反。与未研究的非真实物体相比，AD患者对已研究的非真实物体的分类决策较慢，而NC参与者的此类决策较快。两组对重复的非真实物体的分类决策准确性较低。这些结果支持了这样的观点，即患有轻度认知障碍的AD患者表现出正常的知觉启动效应。从当来源回忆无法抵消熟悉度影响时发生的决策冲突角度讨论了AD患者对已研究的非真实物体的抑制作用。
