a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
J Clin Exp Neuropsychol. 2013;35(9):946-59. doi: 10.1080/13803395.2013.838942. Epub 2013 Sep 30.
Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.
重复学习机制的研究在遗忘型轻度认知障碍中受到限制，而遗忘型轻度认知障碍是阿尔茨海默病的临床前阶段，可以通过认知康复来改变。我们评估了重复的情境工作记忆下降作为从三级护理环境中招募的 45 名老年人样本中的遗忘型轻度认知障碍的指标。结果表明，尽管整体认知表现相似，但情境工作记忆障碍可区分有临床前疾病的成年人和没有认知障碍的成年人，并且与标准护理神经心理学测量相比，该指标具有判别效度。情境工作记忆障碍可能是阿尔茨海默病转化风险的新预测指标。
