Tan R X, Tang H Q, Hu J, Shuai B
Department of Biological Science & Technology, Nanjing University, P.R. China.
Phytochemistry. 1998 Sep;49(1):157-61. doi: 10.1016/s0031-9422(97)00889-3.
The aerial parts of Artemisia sieversiana afforded, in addition to beta-sitosterol, stigmasterol and daucosterol, two novel lignans as well as one known and three new guaianolides. The roots of Inula racemosa gave beta-sitosterol, daucosterol and isoalantolactone. The structures were determined by a combination of spectral methods (IR, EIMS, 1H and 13C NMR, DEPT, COSY, NOESY and HETCOR). All isolates were subjected to antifungal tests. Isoalantolactone, a major sesquiterpene lactone of I. racemosa, was found to be active against the human pathogenic fungi. Aspergillus flavus, A. niger, Geotrichum candidum, Candida tropicalis and C. albicans at concentrations of 50, 50, 25, 25 and 25 micrograms/ml, respectively. The taxonomic significance of the characterized constituents is discussed briefly.
除β-谷甾醇、豆甾醇和胡萝卜苷外，西伯利亚艾蒿地上部分还提供了两种新型木脂素以及一种已知的和三种新的愈创木烷型倍半萜内酯。总状土木香根含有β-谷甾醇、胡萝卜苷和异土木香内酯。通过光谱方法（红外光谱、电子轰击质谱、1H和13C核磁共振、无畸变极化转移增强、化学位移相关谱、核Overhauser效应谱和异核多量子相干谱）相结合确定了结构。对所有分离物进行了抗真菌测试。发现异土木香内酯，总状土木香的一种主要倍半萜内酯，分别在浓度为50、50、25、25和25微克/毫升时对人类致病真菌黄曲霉、黑曲霉、白地霉、热带假丝酵母和白色念珠菌具有活性。简要讨论了所鉴定成分的分类学意义。
