视神经炎后5年脑脊液寡克隆区带对多发性硬化症的预测价值。视神经炎研究组。

The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis. Optic Neuritis Study Group.

作者信息

Cole S R, Beck R W, Moke P S, Kaufman D I, Tourtellotte W W

机构信息

Jaeb Center for Health Research Inc., Tampa, FL 33613, USA.

出版信息

Neurology. 1998 Sep;51(3):885-7. doi: 10.1212/wnl.51.3.885.

DOI:10.1212/wnl.51.3.885

PMID:9748050

Abstract

The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the results suggest that CSF analysis is only useful in the risk assessment of optic neuritis patients when brain MRI is normal and is not of predictive value when brain MRI lesions are present at the time of optic neuritis.

摘要

在参与视神经炎治疗试验的76例患者中，评估了脑脊液寡克隆区带对视神经炎后5年内临床确诊多发性硬化症（CDMS）发生的预测价值。寡克隆区带的存在与CDMS的发生相关（p = 0.02）。然而，结果表明，仅在脑部MRI正常时，脑脊液分析对视神经炎患者的风险评估才有用，而在视神经炎时存在脑部MRI病变的情况下则没有预测价值。