Woodside B, Abizaid A, Caporale M
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Québec, Canada.
Physiol Behav. 1998 Jun 1;64(3):409-14. doi: 10.1016/s0031-9384(98)00128-0.
In lactating rats, food restriction for the first two weeks postpartum extends the period of lactational diestrus by about 1 week. In these studies we investigated whether this effect results from caloric restriction or the reduced availability of a specific macronutrient. In Experiment 1 lactating rats nursing litters of eight pups were assigned to one of four conditions: 1) ad lib. fed; 2) protein-restricted; 3) carbohydrate-restricted; and 4) fat-restricted. Animals in all the restricted conditions were given access to 50% of ad lib. intake of the appropriate nutrient for Days 1-14 postpartum and ad lib. access to the other two macronutrients. In Experiment 2, ad lib. supplementation from one macronutrient source was provided to lactating rats given restricted access to a composite diet. No differential effect of specific macronutrient deprivation or supplementation on length of lactational diestrus was observed in these studies. Thus, the results of both studies are consistent with the hypothesis that caloric restriction plays a primary role in inducing the prolongation of lactational diestrus in food-restricted rats.
在哺乳期大鼠中，产后头两周限制食物摄入可使哺乳期静止期延长约1周。在这些研究中，我们调查了这种效应是由热量限制还是特定常量营养素的可利用性降低所致。在实验1中，哺乳8只幼崽的哺乳期大鼠被分配到以下四种情况之一：1）自由采食；2）蛋白质限制；3）碳水化合物限制；4）脂肪限制。在产后第1 - 14天，所有限制条件下的动物均可摄入其自由采食量50%的相应营养素，而对其他两种常量营养素则可自由采食。在实验2中，给限制摄入复合日粮的哺乳期大鼠补充一种常量营养素来源的自由采食。在这些研究中，未观察到特定常量营养素剥夺或补充对哺乳期静止期长度有差异影响。因此，两项研究的结果均与以下假设一致，即热量限制在诱导食物受限大鼠哺乳期静止期延长中起主要作用。
