When placebo controlled trials are essential and equivalence trials are inadequate.
作者信息
Tramèr M R, Reynolds D J, Moore R A, McQuay H J
机构信息
Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford OX3 7LJ.
出版信息
BMJ. 1998 Sep 26;317(7162):875-80. doi: 10.1136/bmj.317.7162.875.
Abstract
摘要
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When placebo controlled trials are essential and equivalence trials are inadequate.当安慰剂对照试验必不可少且等效性试验不充分时。
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本文引用的文献
1
Size is everything--large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects.样本量至关重要——估计治疗效果的方向和程度时，需要大量信息来克服随机效应。
Pain. 1998 Dec;78(3):209-216. doi: 10.1016/S0304-3959(98)00140-7.
2
Local research ethics committees. Oxford committee was concerned that trial might be unethical.当地研究伦理委员会。牛津委员会担心该试验可能不符合伦理道德。
BMJ. 1997 Nov 29;315(7120):1464.
3
Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo-controlled trials.
Anesthesiology. 1997 Dec;87(6):1277-89. doi: 10.1097/00000542-199712000-00004.
4
Local research ethics committees. National research ethics committee is needed.当地研究伦理委员会。需要国家研究伦理委员会。
BMJ. 1997 Jul 5;315(7099):60-1.
5
Pain relief from intra-articular morphine after knee surgery: a qualitative systematic review.膝关节手术后关节腔内注射吗啡的止痛效果：一项定性系统评价
Pain. 1997 Jun;71(2):127-34. doi: 10.1016/s0304-3959(97)03344-7.
6
Meta-analytic comparison of prophylactic antiemetic efficacy for postoperative nausea and vomiting: propofol anaesthesia vs omitting nitrous oxide vs total i.v. anaesthesia with propofol.术后恶心呕吐预防性止吐效果的荟萃分析比较：丙泊酚麻醉与不使用氧化亚氮 vs 丙泊酚全静脉麻醉
Br J Anaesth. 1997 Mar;78(3):256-9. doi: 10.1093/bja/78.3.256.
7
A quantitative systematic review of ondansetron in treatment of established postoperative nausea and vomiting.昂丹司琼治疗已确诊的术后恶心和呕吐的定量系统评价。
BMJ. 1997 Apr 12;314(7087):1088-92. doi: 10.1136/bmj.314.7087.1088.
8
A systematic review of antidepressants in neuropathic pain.抗抑郁药治疗神经性疼痛的系统评价。
Pain. 1996 Dec;68(2-3):217-27. doi: 10.1016/s0304-3959(96)03140-5.
9
Are research ethics committees behaving unethically? Some suggestions for improving performance and accountability.研究伦理委员会的行为是否不道德？关于提高绩效和问责制的一些建议。
BMJ. 1996 Nov 30;313(7069):1390-3. doi: 10.1136/bmj.313.7069.1390.
10
Placebo mania. Placebos are essential when extent and variability of placebo response are unknown.安慰剂狂热。当安慰剂反应的程度和变异性未知时，安慰剂至关重要。
BMJ. 1996 Oct 19;313(7063):1008. doi: 10.1136/bmj.313.7063.1008a.
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