Harrigan G G, Luesch H, Yoshida W Y, Moore R E, Nagle D G, Paul V J, Mooberry S L, Corbett T H, Valeriote F A
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
J Nat Prod. 1998 Sep;61(9):1075-7. doi: 10.1021/np980321c.
A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.
从关岛附近采集的海洋蓝藻Symploca hydnoides中分离出了一种新的多拉司他汀10（1）的实体瘤选择性细胞毒性类似物。这种代谢产物被赋予了俗名symplostatin 1（2）。这一发现支持了以下观点：从多拉司他汀的原始来源——海兔Dolabella auricularia中分离出的许多化合物都来源于饮食。
