Tezuka Y, Kikuchi T, Zhao W, Chen J, Guo Y
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan, and Research Institute for Medical and Pharmaceutical Science, Dalian, Chunyangji.
J Nat Prod. 1998 Sep;61(9):1078-81. doi: 10.1021/np980150b.
Roots and rhizomes of Veratrum patulum L. (Liliaceae), used as a source of the Chinese crude drug "Li-lu", have yielded two new steroidal alkaloids, 20-isoveratramine (1) and verapatuline (2), along with three known alkaloids, veratramine (3), veratrosine (4), and jervine (5). Structures of new alkaloids 1 and 2 were determined to be a C-20 epimer of 3 and N-(methoxycarbonyl)jervine, respectively, by the use of spectral data including 2D NMR.
作为中药“藜芦”来源的狭叶藜芦（藜芦科）的根及根茎，已分离得到两种新的甾体生物碱，20 -异藜芦胺（1）和藜芦帕图林（2），以及三种已知生物碱，藜芦胺（3）、藜芦宁（4）和介藜芦碱（5）。通过包括二维核磁共振在内的光谱数据确定，新生物碱1和2的结构分别为3的C - 20差向异构体和N -（甲氧基羰基）介藜芦碱。
