Takasaki M, Yamauchi I, Haruna M, Konoshima T
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan, and Faculty of Pharmacy, Meijo University, Yagotoyama, Tenpaku-ku, Nagoya 468-0077, Japan.
J Nat Prod. 1998 Sep;61(9):1105-9. doi: 10.1021/np980148k.
A new phenethyl alcohol glycoside, galactosylmartynoside (1), and a new abietatriene-type diterpene glycoside, ajugaside A (2), were isolated from the whole plants of Ajuga decumbens, together with known phenethyl alcohol glycosides (3 and 4) and iridoid glycosides (5-7). Chemical structures were elucidated on the basis of spectral data. Of these compounds, 8-acetylharpagide (6) exhibited the strongest inhibitory effect on Epstein-Barr virus activation induced by 12-O-tetradecanoylphorbol-13-acetate.
从平卧筋骨草全草中分离得到一个新的苯乙醇苷类化合物，半乳糖马钱苷（1），一个新的枞三烯型二萜苷类化合物，筋骨草苷A（2），以及已知的苯乙醇苷类化合物（3和4）和环烯醚萜苷类化合物（5 - 7）。通过光谱数据阐明了其化学结构。在这些化合物中，8-乙酰哈帕苷（6）对由12-O-十四酰佛波醇-13-乙酸酯诱导的Epstein-Barr病毒激活表现出最强的抑制作用。
