Mao Xu-Dong, Chou Gui-Xin, Zhao Sen-Miao, Zhang Cheng-Gang
The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.
Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China.
Molecules. 2016 Dec 21;21(12):1749. doi: 10.3390/molecules21121749.
In our continued investigations of the plant , five new iridoid glucosides -, including two -isomers, and , along with six known compounds -, were isolated from the -butyl alcohol (-BuOH) soluble fraction of whole dried material of . Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds, - and exhibited potent inhibition of α-glucosidase.
在我们对该植物的持续研究中，从该植物全株干燥材料的正丁醇（-BuOH）可溶部分中分离出了5种新的环烯醚萜苷，包括两种异构体和，以及6种已知化合物。通过包括一维和二维核磁共振（NMR）以及高分辨率电喷雾电离质谱（HR-ESI-MS）在内的光谱技术组合确定了它们的结构。此外，对所有分离物进行了酵母α-葡萄糖苷酶抑制作用评估。在这些化合物中，和对α-葡萄糖苷酶表现出强效抑制作用。
