日本慢生根瘤菌FixK2，是FixLJ依赖性调控级联中控制低氧水平诱导基因的关键调控因子。
Bradyrhizobium japonicum FixK2, a crucial distributor in the FixLJ-dependent regulatory cascade for control of genes inducible by low oxygen levels.
作者信息
Nellen-Anthamatten D, Rossi P, Preisig O, Kullik I, Babst M, Fischer H M, Hennecke H
机构信息
Mikrobiologisches Institut, Eidgenössische Technische Hochschule, CH-8092 Zürich, Switzerland.
出版信息
J Bacteriol. 1998 Oct;180(19):5251-5. doi: 10.1128/JB.180.19.5251-5255.1998.
Abstract
Bradyrhizobium japonicum possesses a second fixK-like gene, fixK2, in addition to the previously identified fixK1 gene. The expression of both genes depends in a hierarchical fashion on the low-oxygen-responsive two-component regulatory system FixLJ, whereby FixJ first activates fixK2, whose product then activates fixK1. While the target genes for control by FixK1 are unknown, there is evidence for activation of the fixNOQP, fixGHIS, and rpoN1 genes and some heme biosynthesis and nitrate respiration genes by FixK2. FixK2 also regulates its own structural gene, directly or indirectly, in a negative way.
摘要
除了先前鉴定出的固氮调节基因fixK1外，日本慢生根瘤菌还拥有第二个类fixK基因fixK2。这两个基因的表达以分级方式依赖于低氧响应双组分调节系统FixLJ，其中FixJ首先激活fixK2，其产物随后激活fixK1。虽然FixK1控制的靶基因尚不清楚，但有证据表明fixK2可激活fixNOQP、fixGHIS和rpoN1基因以及一些血红素生物合成和硝酸盐呼吸基因。FixK2还以负向方式直接或间接调节其自身的结构基因。
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