[Regional chemotherapy in experimental cholangiocarcinoma in pigs].

BACKGROUND

Primary cholangiocarcinoma (PCC) accounts for cca 9% of all carcinomas of the liver and biliary system. Its prognosis of always unfavourable and treatment is difficult.

METHODS AND RESULTS

In 25 pigs strain BU PCC was induced chemically with the aim to test the action of regional chemotherapy on the tumor tissue. For treatment 5-fluorouracil, 5-fluoro-2-deoxyuridine, mitomycin C and doxorubicin was used either as monotherapy or in combinations. During chemotherapy a significant reduction of the tumour or fibrotization occurred, as compared with animals not receiving treatment. The median of survival was prolonged from 51.3 to 210.3 days.

CONCLUSIONS

Regional chemotherapy is a significant constituent of oncological treatment of PCC. Complications of treatment are negligible and the rest for further treatment are encouraging.