Dufek V, Petrtýl J
I. interní klinika 1. LF UK a VFN, Praha.
Cas Lek Cesk. 1998 Aug 3;137(15):464-6.
Primary cholangiocarcinoma (PCC) accounts for cca 9% of all carcinomas of the liver and biliary system. Its prognosis of always unfavourable and treatment is difficult.
In 25 pigs strain BU PCC was induced chemically with the aim to test the action of regional chemotherapy on the tumor tissue. For treatment 5-fluorouracil, 5-fluoro-2-deoxyuridine, mitomycin C and doxorubicin was used either as monotherapy or in combinations. During chemotherapy a significant reduction of the tumour or fibrotization occurred, as compared with animals not receiving treatment. The median of survival was prolonged from 51.3 to 210.3 days.
Regional chemotherapy is a significant constituent of oncological treatment of PCC. Complications of treatment are negligible and the rest for further treatment are encouraging.
原发性胆管癌（PCC）约占肝脏和胆道系统所有癌症的9%。其预后一直不佳，治疗困难。
在25头BU品系猪中通过化学方法诱导PCC，目的是测试区域化疗对肿瘤组织的作用。治疗使用了5-氟尿嘧啶、5-氟-2-脱氧尿苷、丝裂霉素C和阿霉素，单独使用或联合使用。与未接受治疗的动物相比，化疗期间肿瘤明显缩小或出现纤维化。中位生存期从51.3天延长至210.3天。
区域化疗是PCC肿瘤治疗的重要组成部分。治疗并发症可忽略不计，进一步治疗的前景令人鼓舞。
