Li W, Stolovitzky G, Bernaola-Galván P, Oliver J L
Laboratory of Statistical Genetics, Rockefeller University, New York, New York 10021 USA.
Genome Res. 1998 Sep;8(9):916-28. doi: 10.1101/gr.8.9.916.
The heterogeneity within, and similarities between, yeast chromosomes are studied. For the former, we show by the size distribution of domains, coding density, size distribution of open reading frames, spatial power spectra, and deviation from binomial distribution for C + G% in large moving windows that there is a strong deviation of the yeast sequences from random sequences. For the latter, not only do we graphically illustrate the similarity for the above mentioned statistics, but we also carry out a rigorous analysis of variance (ANOVA) test. The hypothesis that all yeast chromosomes are similar cannot be rejected by this test. We examine the two possible explanations of this interchromosomal uniformity: a common origin, such as genome-wide duplication (polyploidization), and a concerted evolutionary process.
对酵母染色体内部的异质性以及它们之间的相似性进行了研究。对于前者，我们通过结构域的大小分布、编码密度、开放阅读框的大小分布、空间功率谱以及大滑动窗口中C + G%的二项分布偏差表明，酵母序列与随机序列存在强烈偏差。对于后者，我们不仅以图形方式说明了上述统计数据的相似性，还进行了严格的方差分析（ANOVA）测试。该测试不能拒绝所有酵母染色体相似的假设。我们研究了这种染色体间一致性的两种可能解释：共同起源，如全基因组复制（多倍体化），以及协同进化过程。
