Transfer RNA and aminoacyl tRNA synthetases in hormone dependent and independent mammary tumors of GR mice: I. Comparative study of the amino acid accepting capacity of the tRNA's in the presence of the homologous and heterologous enzymes.

Transfer RNA and aminoacyl tRNA synthetases were obtained from hormone dependent and independent mammary tumors of GR mice. We have studied the possible changes in the tRNA level by comparing the specific activities of the hormone dependent and independent mammary tumor tRNA's, but no differences were observed. Differences were found in the ability of enzymes from normal male GR mice liver, independent mammary tumor and dependent mammary tumor to cross-react with heterologous tRNA.