Kowalczyk A P, Bornslaeger E A, Norvell S M, Palka H L, Green K J
Department of Pathology, R.H. Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Int Rev Cytol. 1999;185:237-302. doi: 10.1016/s0074-7696(08)60153-9.
Cell-cell adhesion is thought to play important roles in development, in tissue morphogenesis, and in the regulation of cell migration and proliferation. Desmosomes are adhesive intercellular junctions that anchor the intermediate filament network to the plasma membrane. By functioning both as an adhesive complex and as a cell-surface attachment site for intermediate filaments, desmosomes integrate the intermediate filament cytoskeleton between cells and play an important role in maintaining tissue integrity. Recent observations indicate that tissue integrity is severely compromised in autoimmune and genetic diseases in which the function of desmosomal molecules is impaired. In addition, the structure and function of many of the desmosomal molecules have been determined, and a number of the molecular interactions between desmosomal proteins have now been elucidated. Finally, the molecular constituents of desmosomes and other adhesive complexes are now known to function not only in cell adhesion, but also in the transduction of intracellular signals that regulate cell behavior.
细胞间黏附被认为在发育、组织形态发生以及细胞迁移和增殖的调节中发挥重要作用。桥粒是将中间丝网络锚定到质膜的黏附性细胞间连接。通过既作为黏附复合物又作为中间丝的细胞表面附着位点发挥作用，桥粒整合细胞间的中间丝细胞骨架，并在维持组织完整性方面发挥重要作用。最近的观察表明，在自身免疫性疾病和遗传性疾病中，当桥粒分子的功能受损时，组织完整性会受到严重损害。此外，许多桥粒分子的结构和功能已经确定，并且现在已经阐明了桥粒蛋白之间的一些分子相互作用。最后，现在已知桥粒和其他黏附复合物的分子成分不仅在细胞黏附中起作用，而且在调节细胞行为的细胞内信号转导中也起作用。
