Kopelman M D, Stanhope N
Neuropsychiatry and Memory Disorders Clinic, Division of Psychiatry and Psychology, United Medical and Dental Schools of Guy's and St Thomas's Hospital, London, UK.
Neuropsychologia. 1998 Aug;36(8):785-95. doi: 10.1016/s0028-3932(97)00167-x.
Patients with frontal, temporal lobe, or diencephalic lesions were compared with healthy controls on measures of recall and recognition memory for word lists. Exposure times were titrated to match recognition memory scores 30 s after the end of word-list presentation as closely as possible. Using this technique, we failed to find a disproportionate impairment in recall memory in either the frontal lobe lesion patients or in the amnesic (temporal lobe and diencephalic) patients, compared with healthy controls. Consistent with this finding, performance on these tasks showed highly significant correlations with anterograde memory quotients (despite the titration procedure), but not with executive/frontal function tasks. On the other hand, the frontal lobe lesion group showed disproportionate benefit in the recall of semantically categorised words, compared with unrelated words. This may indicate an impairment in retrieval or access, compared with the amnesic (temporal lobe and diencephalic) patients, and/or an inability to organise their learning of unrelated words spontaneously, compared with healthy controls.
我们将额叶、颞叶或间脑病变患者与健康对照者进行了比较，比较内容为对单词列表的回忆和识别记忆测试。单词列表呈现结束30秒后，调整曝光时间，尽可能使识别记忆分数相匹配。使用该技术，我们未发现额叶病变患者或遗忘症（颞叶和间脑）患者在回忆记忆方面与健康对照者相比存在不成比例的损害。与这一发现一致，这些任务的表现与顺行性记忆商数高度相关（尽管采用了滴定程序），但与执行/额叶功能任务无关。另一方面，与无关单词相比，额叶病变组在语义分类单词的回忆方面表现出不成比例的优势。与遗忘症（颞叶和间脑）患者相比，这可能表明在检索或获取方面存在损害，和/或与健康对照者相比，无法自发组织对无关单词的学习。
