Päi S, Päi L, Birkenfeldt R
Department of Internal Medicine, Faculty of Medicine, University of Tartu, Estonia.
Scand J Rheumatol. 1998;27(4):252-6. doi: 10.1080/030097498442352.
In the present study, the IgA rheumatoid factor (IgA RF) was assayed by ELISA in 114 sera of patients with active RA. IgA RF was found in the sera of 38 (33.3%) patients. A total of 56 disease variables were studied, differences in variables between IgA RF positive and negative patients were analyzed. The presence of IgA RF was found to be associated with a rapid progressive course, RA activity, onset of extra-articular manifestations (especially systemic rheumatoid vasculitis), high IgM RF titres, circulating immune complexes, cryoglobulins, and C-reactive protein levels. There was no statistically significant difference in serum IgA levels between IgA RF seropositive and seronegative patients. The presence of IgA RF showed a positive correlation with the level of IgM RF. The results of this study showed that the determination of IgA RF has a practical use in the establishment of the severe course of RA with systemic damages.
在本研究中，采用酶联免疫吸附测定法（ELISA）检测了114例活动期类风湿关节炎（RA）患者血清中的IgA类风湿因子（IgA RF）。在38例（33.3%）患者的血清中发现了IgA RF。共研究了56项疾病变量，分析了IgA RF阳性和阴性患者之间变量的差异。发现IgA RF的存在与疾病快速进展过程、RA活动度、关节外表现（尤其是系统性类风湿血管炎）的出现、高IgM RF滴度、循环免疫复合物、冷球蛋白及C反应蛋白水平相关。IgA RF血清阳性和血清阴性患者之间的血清IgA水平无统计学显著差异。IgA RF的存在与IgM RF水平呈正相关。本研究结果表明，IgA RF的检测在确定伴有全身损害的严重RA病程方面具有实际应用价值。
