红系和巨核系基因在急性红白血病（FAB M6）和急性巨核细胞白血病（FAB M7）中的共表达。

Coexpression of erythroid and megakaryocytic genes in acute erythroblastic (FAB M6) and megakaryoblastic (FAB M7) leukaemias.

作者信息

Linari S, Vannucchi A M, Ciolli S, Leoni F, Caporale R, Grossi A, Pagliai G, Santini V, Paoletti F, Ferrini P R

机构信息

Division of Haematology, Careggi Hospital, Florence, Italy.

出版信息

Br J Haematol. 1998 Sep;102(5):1335-7. doi: 10.1046/j.1365-2141.1998.00904.x.

DOI:10.1046/j.1365-2141.1998.00904.x

PMID:9753066

Abstract

There is evidence to suggest a close relationship between the erythroid and megakaryocytic lineages. Using RT-PCR, we evaluated the coexpression of erythroid and megakaryocytic genes in blasts from 25 acute myeloid leukaemia (AML) cases (FAB M1-M7) and three unclassifiable leukaemias with trilineage dysplasia (trilineal AML). All FAB M6 and M7 and trilineal leukaemias expressed mRNAs for alpha-globin, glycoprotein IIb (GpIIb), erythropoietin receptor (Epo-R) and thrombopoietin receptor (c-mpl), but not for myeloperoxidase (MPO) which in contrast was expressed in the other FAB-subtype leukaemias. These data support the hypothesis that blasts from M7 and M6 leukaemias may derive from (or represent) a common progenitor cell with resident bipotentiality towards the megakaryocytic and erythrocytic lineages.

摘要

有证据表明红系和巨核系之间存在密切关系。我们运用逆转录聚合酶链反应（RT-PCR），评估了25例急性髓系白血病（AML，FAB M1 - M7）患者以及3例具有三系发育异常的不可分类白血病（三系AML）原始细胞中红系和巨核系基因的共表达情况。所有FAB M6和M7以及三系白血病均表达α-珠蛋白、糖蛋白IIb（GpIIb）、促红细胞生成素受体（Epo-R）和血小板生成素受体（c-mpl）的信使核糖核酸（mRNA），但不表达髓过氧化物酶（MPO），相反，MPO在其他FAB亚型白血病中表达。这些数据支持了这样的假说，即M7和M6白血病的原始细胞可能源自（或代表）一种对巨核系和红系具有双潜能的共同祖细胞。