Heitkemper M, Burr R L, Jarrett M, Hertig V, Lustyk M K, Bond E F
Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle 98195, USA.
Dig Dis Sci. 1998 Sep;43(9):2093-8. doi: 10.1023/a:1018871617483.
Autonomic nervous system function was assessed in women with and without irritable bowel syndrome using frequency domain measures of heart rate variability. Women were interviewed and placed into the irritable bowel syndrome (N = 25) group based on history of diagnosis and self-report of current gastrointestinal symptoms. Women in the control group denied a history of chronic gastrointestinal symptoms (N = 15). Women were followed for one menstrual cycle with a symptom diary, and during mid-luteal phase they wore a Holter 24-hr electrocardiograph monitor. Women with irritable bowel syndrome demonstrated significantly lower vagal tone as measured by the high frequency spectrum relative to control women. In addition, women with irritable bowel syndrome had a flattened 24-hr pattern of heart rate variability, with significantly lower levels of vagal tone during sleep. These results suggest that systemic sympathovagal balance may be shifted in a subset of women with irritable bowel syndrome.
采用心率变异性频域测量方法，对患有和未患有肠易激综合征的女性的自主神经系统功能进行了评估。根据诊断史和当前胃肠道症状的自我报告，对女性进行访谈并将其分为肠易激综合征组（N = 25）。对照组女性否认有慢性胃肠道症状史（N = 15）。使用症状日记对女性进行了一个月经周期的跟踪，在黄体中期，她们佩戴了24小时动态心电图监测仪。与对照组女性相比，肠易激综合征女性的高频谱测量显示迷走神经张力显著降低。此外，肠易激综合征女性的心率变异性24小时模式变平，睡眠期间迷走神经张力水平显著降低。这些结果表明，一部分肠易激综合征女性的全身交感-迷走神经平衡可能发生了改变。
