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减数分裂端粒:同源染色体的“媒人”

Meiotic telomeres: a matchmaker for homologous chromosomes.

作者信息

Hiraoka Y

机构信息

Kansai Advanced Research Center, Communications Research Laboratory, Kobe, Japan.

出版信息

Genes Cells. 1998 Jul;3(7):405-13. doi: 10.1046/j.1365-2443.1998.00205.x.

Abstract

Telomeres, with their special structures and special schemes of synthesis, are essential for protecting the ends of eukaryotic linear chromosomes during cell proliferation. In addition to this basic function, the meiosis-specific functions of telomeres have long been inferred from the cytological observations of characteristic chromosome configurations in meiotic prophase. Recent studies in the fission yeast Schizosaccharomyces pombe have provided deeper insights into the role of meiotic telomeres in the pairing of homologous chromosomes. Here I have summarized our current understanding of the meiotic behaviour of telomeres in S. pombe, and discuss the role of telomeres in meiosis.

摘要

端粒具有特殊的结构和合成方式,对于在细胞增殖过程中保护真核生物线性染色体的末端至关重要。除了这一基本功能外,长期以来,通过对减数分裂前期特征性染色体构型的细胞学观察,推断出了端粒在减数分裂中的特定功能。最近对裂殖酵母粟酒裂殖酵母的研究,为深入了解减数分裂端粒在同源染色体配对中的作用提供了线索。在此,我总结了我们目前对粟酒裂殖酵母中端粒减数分裂行为的理解,并讨论了端粒在减数分裂中的作用。

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