Löw P, Neipel F, Rascu A, Steininger H, Manger B, Fleckenstein B, Kalden J R, Harrer T
Department of Medicine III with Institute of Clinical Immunology, University of Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany.
Eur J Med Res. 1998 Oct 14;3(10):461-4.
Human herpes virus 8 (HHV-8) seems to be involved in the pathogenesis of Kaposi s sarcoma. In vitro, antiviral drugs with activity against herpes viruses also can suppress HHV-8, however, little is known about the antiviral activity against HHV-8 in vivo. In this report we describe the effects of foscarnet on HHV-8 viremia in an HIV-infected patient with disseminated Kaposi s sarcoma and a presumably HHV-8 associated hemophagocytic syndrome. HHV-8 DNA could be detected in this patient by PCR in peripheral blood mononuclear cells (PBMC), in bronchoalveolar fluid and tumor biopsies. After initiation of foscarnet because of a severe hemophagocytic syndrome HHV-8 PCR turned negative in PBMC, but stayed positive in pleural effusions and in a tumor biopsy. After termination of foscarnet therapy HHV-8 DNA in PBMC persistently reappeared. Under treatment with foscarnet the hemophagocytic syndrome dramatically improved, suggesting that HHV-8 had a pathogenetic role in this syndrome.
人疱疹病毒8型（HHV - 8）似乎与卡波西肉瘤的发病机制有关。在体外，对疱疹病毒有活性的抗病毒药物也能抑制HHV - 8，但关于其在体内对HHV - 8的抗病毒活性知之甚少。在本报告中，我们描述了膦甲酸钠对一名患有播散性卡波西肉瘤且可能伴有HHV - 8相关噬血细胞综合征的HIV感染患者的HHV - 8病毒血症的影响。通过PCR可在该患者的外周血单核细胞（PBMC）、支气管肺泡灌洗液和肿瘤活检组织中检测到HHV - 8 DNA。由于严重的噬血细胞综合征开始使用膦甲酸钠治疗后，PBMC中的HHV - 8 PCR检测结果转为阴性，但在胸腔积液和肿瘤活检组织中仍为阳性。膦甲酸钠治疗终止后，PBMC中的HHV - 8 DNA持续再次出现。在膦甲酸钠治疗下，噬血细胞综合征显著改善，提示HHV - 8在该综合征中具有致病作用。
