Schnohr P, Nyboe J, Lange P, Jensen G
Epidemiological Research Unit, National University Hospital, Copenhagen, Denmark.
J Gerontol A Biol Sci Med Sci. 1998 Sep;53(5):M347-50. doi: 10.1093/gerona/53a.5.m347.
We have previously reported that men who look older than their contemporaries have a significantly higher risk for myocardial infarction. The purpose of this study was to investigate whether persons with pronounced aging signs such as graying of hair, baldness, or facial wrinkles are prone to a shorter life span compared to their contemporaries.
In the Copenhagen City Heart Study comprising a random sample of 20,000 men and women, we also recorded, in addition to cardiovascular risk factors, data on signs of aging: extent of gray hair, baldness, facial wrinkles, and arcus senilis (corneal arcus). During 16 years of follow-up, 3,939 persons (1,656 women and 2,283 men) had died. The Cox regression model for proportional hazards, which included age as an explanatory variable, was used for descriptive analysis of the correlation between these aging signs and all-cause mortality.
We found no correlation between the mortality and the extent of graying of the hair, or baldness or facial wrinkles in either of the sexes, irrespective of age. A single exception was observed in a small subgroup of men with no gray hair. They had a slightly, but significantly, lower mortality than the rest [relative risk (RR) = .81, 95% confidence interval (CI) .67-.98; p < .05]. The presence of arcus senilis was significantly correlated with a shorter life span in women (RR = 1.25, 95% CI 1.08-1.46; p < .01). For men the same tendency was found, but the correlation was not statistically significant.
We conclude that the degrees of graying of the hair, baldness, and facial wrinkles are not predictive of a shorter life span in men and women in the Copenhagen City Heart Study.
我们之前曾报道，看起来比同龄人老的男性患心肌梗死的风险显著更高。本研究的目的是调查有明显衰老迹象（如头发变白、秃顶或面部皱纹）的人与同龄人相比是否更容易寿命较短。
在哥本哈根市心脏研究中，该研究对20,000名男性和女性进行了随机抽样，除心血管危险因素外，我们还记录了衰老迹象的数据：白发程度、秃顶、面部皱纹和角膜老年环。在16年的随访期间，有3,939人（1,656名女性和2,283名男性）死亡。使用包含年龄作为解释变量的Cox比例风险回归模型对这些衰老迹象与全因死亡率之间的相关性进行描述性分析。
我们发现，无论年龄大小，头发变白程度、秃顶或面部皱纹与两性的死亡率均无相关性。在一小部分没有白发的男性亚组中观察到一个例外。他们的死亡率略低，但显著低于其他男性[相对风险（RR）=0.81，95%置信区间（CI）0.67 - 0.98；p < 0.05]。角膜老年环的存在与女性寿命较短显著相关（RR = 1.25，95% CI 1.08 - 1.46；p < 0.01）。男性也有同样的趋势，但相关性无统计学意义。
我们得出结论，在哥本哈根市心脏研究中，头发变白程度、秃顶和面部皱纹程度不能预测男性和女性的寿命较短。
