cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil.

作者信息

Queiroz D M, Mendes E N, Rocha G A, Oliveira A M, Oliveira C A, Magalhães P P, Moura S B, Cabral M M, Nogueira A M

机构信息

Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

出版信息

Int J Cancer. 1998 Oct 5;78(2):135-9. doi: 10.1002/(sici)1097-0215(19981005)78:2<135::aid-ijc1>3.0.co;2-#.

To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.