膝关节置换术中深静脉血栓的预防。低分子量肝素与足部泵压对比的随机对照研究初步结果。
Prevention of deep vein thrombosis in knee arthroplasty. Preliminary results from a randomized controlled study of low molecular weight heparin vs foot pump compression.
作者信息
Norgren L, Toksvig-Larsen S, Magyar G, Lindstrand A, Albrechtsson U
机构信息
Department of Orthopedic Surgery, Lund University, Sweden.
出版信息
Int Angiol. 1998 Jun;17(2):93-6.
BACKGROUND
We evaluated in a randomized controlled study the possibility to use foot pump mechanical compression compared to routine LMWH as prophylaxis against deep vein thrombosis during knee arthroplasty.
METHODS
Forty patients were included in this preliminary report. Eleven patients withdrew, usually during the early phase of the study.
RESULTS
Among the 29 patients completing a venography, 27% in the compression group and none in the LMWH group had a DVT. This difference was statistically significant (p<0.05). One further patient in the compression group died from pulmonary embolism 17 days postoperatively.
CONCLUSIONS
With the present study protocol, mechanical foot pump compression failed to be as efficient as LMWH prophylaxis.
背景
在一项随机对照研究中，我们评估了与常规低分子肝素（LMWH）相比，使用足部泵机械加压预防膝关节置换术中深静脉血栓形成的可能性。
方法
本初步报告纳入了40例患者。11例患者退出，通常是在研究早期。
结果
在完成静脉造影的29例患者中，加压组27%发生深静脉血栓形成，低分子肝素组无1例发生。这种差异具有统计学意义（p<0.05）。加压组另有1例患者术后17天死于肺栓塞。
结论
按照本研究方案，足部泵机械加压预防深静脉血栓形成的效果不如低分子肝素。
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