Nakano M, Kurokawa M, Hozumi T, Saito A, Ida M, Morohashi M, Namba T, Kawana T, Shiraki K
Department of Virology, Toyama Medical and Pharmaceutical University, Japan.
Antiviral Res. 1998 Jul;39(1):25-33. doi: 10.1016/s0166-3542(98)00023-0.
Rhus javanica has been shown to exhibit anti-herpes simplex virus (HSV) activity and potentiate the anti-HSV activity of acyclovir in vitro and in vivo. This extract was examined for its suppressive efficacy on recurrent genital infection in guinea pigs. Guinea pigs were primarily infected intravaginally with HSV type 2 (HSV-2). Prophylactic oral administration, at the dose corresponding to human use, of R. javanica significantly reduced the incidence, severity and/or frequency of spontaneous and severe skin lesions as compared with latently infected guinea pigs administered with water. This prophylactic efficacy was confirmed by the crossover administration, for more than 2 months, of R. javanica and water to the infected guinea pigs. Toxicity, such as weight loss, from R. javanica administration was not observed in the guinea pigs. When recurrent HSV-2 disease was induced by ultraviolet irradiation 3 months after primary infection, the prophylaxis with R. javanica was also significantly effective in reducing the severity of ultraviolet-induced skin lesions. Thus, prophylaxis of recurrent genital HSV-2 infection with R. javanica may preserve the efficacy of acyclovir by reducing both the use of acyclovir and the appearance of acyclovir-resistant viruses.
已证明盐肤木在体外和体内均表现出抗单纯疱疹病毒（HSV）活性，并能增强阿昔洛韦的抗HSV活性。对该提取物在豚鼠复发性生殖器感染方面的抑制效果进行了研究。豚鼠经阴道初次感染2型单纯疱疹病毒（HSV-2）。以相当于人类使用的剂量对豚鼠进行盐肤木预防性口服给药，与给予水的潜伏感染豚鼠相比，显著降低了自发和严重皮肤病变的发生率、严重程度和/或频率。对感染的豚鼠交叉给予盐肤木和水超过2个月，证实了这种预防效果。在豚鼠中未观察到盐肤木给药引起的诸如体重减轻等毒性。在初次感染3个月后通过紫外线照射诱发复发性HSV-2疾病时，盐肤木预防在减轻紫外线诱发的皮肤病变严重程度方面也具有显著效果。因此，用盐肤木预防复发性生殖器HSV-2感染可能通过减少阿昔洛韦的使用和阿昔洛韦耐药病毒的出现来保持阿昔洛韦的疗效。
