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芽殖酵母中的DNA损伤检查点。

DNA damage checkpoint in budding yeast.

作者信息

Longhese M P, Foiani M, Muzi-Falconi M, Lucchini G, Plevani P

机构信息

Dipartimento di Genetica e Biologia dei Microrganismi, Via Celoria 26, 20133 Milano, Italy.

出版信息

EMBO J. 1998 Oct 1;17(19):5525-8. doi: 10.1093/emboj/17.19.5525.

DOI:10.1093/emboj/17.19.5525
PMID:9755152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1170880/
Abstract

Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinate cell-cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has been invaluable in dissecting genetically the DNA damage checkpoint pathway. Recent results on posttranslational modifications and protein-protein interactions of some key factors provide new insights into the architecture of checkpoint protein complexes and their order of function.

摘要

真核细胞已经进化出一个被称为关卡的控制机制网络，该网络根据内部和外部信号来协调细胞周期进程。酿酒酵母在从遗传学角度剖析DNA损伤关卡途径方面具有极高价值。近期关于一些关键因子的翻译后修饰和蛋白质-蛋白质相互作用的研究结果，为关卡蛋白复合物的结构及其功能顺序提供了新的见解。

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本文引用的文献

1
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.Mec1p对于酵母DNA损伤检查点蛋白Ddc1p的磷酸化至关重要，而Ddc1p与Mec3p存在物理相互作用。
EMBO J. 1998 Jul 15;17(14):4199-209. doi: 10.1093/emboj/17.14.4199.
2
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.在DNA损伤检查点中，Rad53 FHA结构域与磷酸化的Rad9相关联。
Science. 1998 Jul 10;281(5374):272-4. doi: 10.1126/science.281.5374.272.
3
DNA damage checkpoints update: getting molecular.DNA损伤检查点的更新：深入分子层面
Curr Opin Genet Dev. 1998 Apr;8(2):185-93. doi: 10.1016/s0959-437x(98)80140-8.
4
RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation.RAD9和RAD24定义了芽殖酵母中DNA损伤检查点途径的两个相加且相互作用的分支，这两个分支通常是Rad53修饰和激活所必需的。
EMBO J. 1998 May 1;17(9):2687-98. doi: 10.1093/emboj/17.9.2687.
5
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage.Hus1p是一种保守的裂殖酵母检查点蛋白，它与Rad1p相互作用，并在DNA损伤时发生磷酸化。
EMBO J. 1998 Apr 1;17(7):2055-66. doi: 10.1093/emboj/17.7.2055.
6
G2/M checkpoint genes of Saccharomyces cerevisiae: further evidence for roles in DNA replication and/or repair.酿酒酵母的G2/M期检验点基因：在DNA复制和/或修复中发挥作用的进一步证据
Mol Gen Genet. 1997 Nov;256(6):638-51. doi: 10.1007/s004380050612.
7
The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway.酿酒酵母Pds1p的后期抑制因子是DNA损伤检查点途径的一个靶点。
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14361-6. doi: 10.1073/pnas.94.26.14361.
8
Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae.在酿酒酵母中，Rad53依赖的Swi6磷酸化以及CLN1和CLN2转录的下调是对DNA损伤的响应。
Genes Dev. 1997 Nov 15;11(22):3032-45. doi: 10.1101/gad.11.22.3032.
9
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.复制因子C组分Rfc5是酵母检查点途径中Rad53蛋白激酶调控所必需的。
Mol Cell Biol. 1997 Oct;17(10):5905-14. doi: 10.1128/MCB.17.10.5905.
10
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.新型DNA损伤检查点蛋白ddc1p在芽殖酵母的细胞周期中周期性磷酸化，并对DNA损伤作出反应。
EMBO J. 1997 Sep 1;16(17):5216-26. doi: 10.1093/emboj/16.17.5216.