芽殖酵母中的DNA损伤检查点。
DNA damage checkpoint in budding yeast.
作者信息
Longhese M P, Foiani M, Muzi-Falconi M, Lucchini G, Plevani P
机构信息
Dipartimento di Genetica e Biologia dei Microrganismi, Via Celoria 26, 20133 Milano, Italy.
出版信息
EMBO J. 1998 Oct 1;17(19):5525-8. doi: 10.1093/emboj/17.19.5525.
Abstract
Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinate cell-cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has been invaluable in dissecting genetically the DNA damage checkpoint pathway. Recent results on posttranslational modifications and protein-protein interactions of some key factors provide new insights into the architecture of checkpoint protein complexes and their order of function.
摘要
真核细胞已经进化出一个被称为关卡的控制机制网络，该网络根据内部和外部信号来协调细胞周期进程。酿酒酵母在从遗传学角度剖析DNA损伤关卡途径方面具有极高价值。近期关于一些关键因子的翻译后修饰和蛋白质-蛋白质相互作用的研究结果，为关卡蛋白复合物的结构及其功能顺序提供了新的见解。
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本文引用的文献
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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.在DNA损伤检查点中，Rad53 FHA结构域与磷酸化的Rad9相关联。
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DNA damage checkpoints update: getting molecular.DNA损伤检查点的更新：深入分子层面
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