Simón C, Moreno C, Remohí J, Pellicer A
Instituto Valenciano de Infertilidad (IVI), Valencia University School of Medicine, Spain.
Hum Reprod. 1998 Jun;13 Suppl 3:219-32; discussion 233-6. doi: 10.1093/humrep/13.suppl_3.219.
Molecular interactions at the embryo-maternal interface at the time of implantation is an exciting field demanding a wide effort in order to understand the crucial process of embryonic implantation. The objective of the present work is to demonstrate the existence of a specific communication pathway (at the molecular level) between embryo and endometrium in the adhesion phase of human embryonic implantation. This pathway of molecular interactions is apparently initiated by the endometrium in the presence of an implanting blastocyst. It is mediated through the embryonic interleukin 0(IL)-1-alpha + IL-1-beta, and the target is the endometrial epithelial beta-3 integrin subunit. If the relevance of beta-3 is accepted as a marker of uterine receptively, these observations may imply that the normal hormonally-regulated human endometrium is the trigger of molecular events preparing the blastocyst to efficiently communicate and regulate endometrial adhesion molecules in order to implant.
着床时胚胎与母体界面的分子相互作用是一个令人兴奋的领域，为了解胚胎着床这一关键过程需要付出广泛的努力。本研究的目的是证明在人类胚胎着床的黏附阶段，胚胎与子宫内膜之间（在分子水平上）存在特定的通讯途径。这种分子相互作用途径显然是由子宫内膜在植入囊胚存在的情况下启动的。它通过胚胎白细胞介素0（IL）-1-α + IL-1-β介导，靶标是子宫内膜上皮β-3整合素亚基。如果β-3的相关性被认为是子宫接受性的标志物，这些观察结果可能意味着正常的激素调节的人类子宫内膜是启动分子事件的触发因素，这些分子事件使囊胚能够有效地通讯并调节子宫内膜黏附分子以便着床。
