Sulon J, Palem-Vliers M, Genard P, Cittanova N, Desfosses B
Clin Chim Acta. 1976 Nov 1;72(3):275-84. doi: 10.1016/0009-8981(76)90189-3.
This paper describes a study of the physico-chemical and radioimmunological properties of three antialdosterone antisera which permitted practical conclusions to be drawn. By its high degree of specificity, anti-aldo-3-oxime-BSA constitutes the most useful antiserum for the clinical assay of aldosterone. The principal advantage of this antiserum is that it allows both urinary and blood aldosterone radioimmunoassay without the necessity of including a chromatographic step. No problems arise with the blanks. This work also includes the study of two anti-deoxycorticosterone antisera. The aldosterone and deoxycorticosterone values, obtained from normal subjects under various physiological conditions, are in agreement with the values given in the literature.
本文描述了对三种抗醛固酮抗血清的物理化学和放射免疫特性的研究，从中得出了一些实用的结论。抗醛固酮-3-肟-牛血清白蛋白（anti-aldo-3-oxime-BSA）因其高度特异性，成为醛固酮临床检测中最有用的抗血清。这种抗血清的主要优点是，它无需色谱步骤即可同时进行尿和血醛固酮的放射免疫测定。空白试验没有问题。这项工作还包括对两种抗脱氧皮质酮抗血清的研究。从正常受试者在各种生理条件下获得的醛固酮和脱氧皮质酮值与文献中给出的值一致。
